In summary, we demonstrated that the DHCR24 inhibitor SH42 induces a profound increase in desmosterol levels in both E3L.CETP mice and LDLr-KO mice without stimulation of lipogenesis or aggravating hyperlipidemia, and even reduces hepatic lipids as shown in E3L.CETP mice. This evidence concerns the gene LDLR and hyperlipidemia.