Although functional evidence does not support the association of Dhcr24 with atherosclerosis in mice and that no variant reaches significance (p = 5.0E-8) in the genomic region of DHCR24 per se in humans (Figure S2, lower panel), we cannot state with certainty that there is no genetic association between the DHCR24 locus and CAD in humans. The gene discussed is DHCR24; the disease is coronary artery disorder.