U2AF2 and frontotemporal dementia: Huan, Jinhe & Rongzong (2019) reported TPX2 as one of the central genes implicated in degenerative meniscus injury in OA. While U2AF2 has been linked to conditions like frontotemporal dementia and spinocerebellar ataxia 1 (Richard et al., 2021; Paulson et al., 2017), its relationship with OA remains less defined.