In the GSE52042 dataset, TPX2 was associated with starch and sucrose metabolism, mismatch repair, and lysosome, while U2AF2 was enriched in the p53 signaling pathway, apoptosis, etc. In the GSE206848 dataset, TPX2-enriched KEGG pathway enrichments included basal transcription factors, WNT signaling pathway, and U2AF2-enriched pathways include prion diseases, etc. This evidence concerns the gene TP53 and prion disease.