Six genes in the MHC Class III region, DDX39B, DXO, LSM2, NELFE, PRRC2A, and SKIV2L, encode RBPs and have a well-defined role in post-transcriptional gene regulation and RNA monitoring, and these genes may have important functions in immunity and be associated with autoimmune diseases (18). This evidence concerns the gene SKIC2 and autoimmune disease.