Six genes in the MHC Class III region, DDX39B, DXO, LSM2, NELFE, PRRC2A, and SKIV2L, encode RBPs and have a well-defined role in post-transcriptional gene regulation and RNA monitoring, and these genes may have important functions in immunity and be associated with autoimmune diseases (18). Here, PRRC2A is linked to autoimmune disease.