found that the KLF4 deficiency in myeloid cells augmented TNF-α production, thereby exacerbating necroptosis of TECs and renal interstitial fibrosis in two murine models of CKD induced by nephrotoxic serum nephritis and unilateral ureteral obstruction, however, this effect was mitigated by macrophage-specific TNF deletion (36). The gene discussed is TNF; the disease is chronic kidney disease.