BMSCs recruited to the tumor microenvironment differentiate into tumor-associated fibroblasts (TAF), which release IL-6, IL-10, C-C chemokine ligand 5 (CCL5), and extracellular matrix remodeling enzymes in the tumor microenvironment to affect tumor cell survival and angiogenesis (Bergfeld and DeClerck, 2010). The gene discussed is CCL5; the disease is neoplasm.