APOE and Alzheimer disease: Different studies have also described that centenarians present a reduced number of cases with neurodegenerative diseases, in some cases avoid dementia, and also display lower levels of Alzheimer's disease (AD) pathology, including beta‐amyloid and ApoE4 allele (Andersen, 2020; Calvert et al., 2006; von Gunten et al., 2010).