Following intraperitoneal delivery of lobeline (5 mg/kg) to nude mice, there was significant reduction in the growing curve, weight, Ki‐67 (proliferation marker) or CD31 (microvessel marker) levels, mitochondrial NADH/NAD+ ratio, lactic acid amount, as well as ATP abundance of hypodermically xenografted tumours formed by SH‐SY5Y cell line, along with increase in body weight and down‐regulation of c‐Myc downstream genes (Figures 6H and S7D‒F). The gene discussed is PECAM1; the disease is neoplasm.