NSUN2 is a well‐characterized RNA methyltransferase, responsible for m5C of tRNA and mRNAs.[10, 13, 17, 18, 19, 35] NSUN2 promotes the progression of multiple cancers via m5C modification of LIN28B, FABP5, p57Kip2, PFAS, TIAM2, and HDGF mRNA in esophageal squamous cell carcinoma, osteosarcoma, gastric cancer, retinoblastoma, pancreatic cancer and bladder cancer, respectively.[10, 18, 43, 44, 45, 46] Correlation analysis further revealed that high levels of NSUN2 were significantly associated with clinical stage, lymph node metastasis, and distant metastasis. Here, NSUN2 is linked to esophageal squamous cell carcinoma.