YBX1, a well‐known m5C‐binding reader protein, functions alongside NSUN2 to enhance the mRNA stability of HDGF in BLCA and the mRNA translation of QSOX1 in non‐small‐cell lung cancer.[10, 11] Then, the analysis of TCGA data further validated the significantly positive correlation between the mRNA expression of ENO1 and those of NSUN2 and YBX1 in CRC. Here, HDGF is linked to bladder transitional cell carcinoma.