YBX1, a well‐known m5C‐binding reader protein, functions alongside NSUN2 to enhance the mRNA stability of HDGF in BLCA and the mRNA translation of QSOX1 in non‐small‐cell lung cancer.[10, 11] Then, the analysis of TCGA data further validated the significantly positive correlation between the mRNA expression of ENO1 and those of NSUN2 and YBX1 in CRC. The gene discussed is YBX1; the disease is colorectal carcinoma.