Recent studies have reported that NSUN2 activation maintains global m5C RNA methylation of several oncogenes, and promotes tumorigenesis and immunotherapy resistance via cGAS‐STING pathway.[41] In accordance with this, significant cGAMP‐induced activation of p‐STING and p‐TBK1 were observed in CRC cell when treated with Nsun2‐i4 (Figure S6H, Supporting Information). The gene discussed is TBK1; the disease is colorectal carcinoma.