Recent studies have reported that NSUN2 activation maintains global m5C RNA methylation of several oncogenes, and promotes tumorigenesis and immunotherapy resistance via cGAS‐STING pathway.[41] In accordance with this, significant cGAMP‐induced activation of p‐STING and p‐TBK1 were observed in CRC cell when treated with Nsun2‐i4 (Figure S6H, Supporting Information). This evidence concerns the gene NSUN2 and colorectal carcinoma.