In patients treated with multiple insulin doses, a randomized clinical trial reported reductions of 43% and 53% on the time spent in hypoglycemia < 3.9 mmol/L (70 mg/dL), reduced by 0.47 ± 0.13 h/day [mean ± SE (p = 0.0006)], and < 3.1 mmol/L (55 mg/dL), reduced by 0.22 ± 0.07 h/day (p = 0.0014), respectively [26]. The gene discussed is INS; the disease is Hypoglycemia.