ZMYND8 and neoplasm: Further studies revealed that RACK7 recruits KDM5C to enhancers site and reduces H3K4me3 levels, thereby repressing the transcription of several oncogenes including S100A. When KDM5C or RACK7 was absent, it led to enhanced invasion and migration of ZR-75-30 cells and promotion of tumor growth in vivo through de-repression of oncogenes [140].