There were decreased p62 protein expression and decreased protein expression ratios of phospho-mTOR/mTOR and phospho-AKT/AKT, while increased Beclin1 protein expression and increased protein expression ratio of LC3B-II/LC3B-I in the liver of Sj + lact group at 8 weeks p.i. compared with Sj group, indicating that blockage of galectin-receptor interaction (e.g. through downregulating Gal-3 expression) may reduce S. japonicum-induced liver fibrosis by promoting autophagy by inhibiting AKT/mTOR signaling pathway activation. The gene discussed is AKT1; the disease is Hepatic fibrosis.