Meanwhile, exposure to high glucose inhibits nuclear factor erythroid 2­related factor 2 (Nrf2)/ Kelch­Like ECH­Associated Protein 1 (Keap1) signalling, leading to oxidative stress induction, assembly of Nlrp3, activation of Caspase1, and subsequent initiation of pyroptosis.This cascade culminates in disrupted bone remodelling and exacerbated osteoporosis [36]. The gene discussed is KEAP1; the disease is osteoporosis.