The results revealed that overexpression of CCL2 could reverse the inhibitory effects of LINC00330 on ESCC cell proliferation (Fig. 8C, and Additional file 3: Figure S7C), invasion (Fig. 8G, and Additional file 3: Figure S7G), and EMT (Fig. 8H, and Additional file 3: Figure S7H). The gene discussed is CCL2; the disease is esophageal squamous cell carcinoma.