To further clarify the role of LINC00330 in ESCC TAM reprogramming, we conducted “ESCC-macrophage coculture experiments.” Initially, we overexpressed or knocked down LINC00330 in ESCC cells (Fig. 4A, and Additional file 3: Figure S3A&E) and collected the conditioned medium. The gene discussed is LINC00330; the disease is esophageal squamous cell carcinoma.