The results showed that overexpression of LINC00330 significantly inhibited the proliferation (Fig. 2A, and Additional file 3: Figure S1D) and invasion (Fig. 2B, and Additional file 3: Figure S1E) of ESCC cells and promoted their apoptosis (Fig. 2C, and Additional file 3: Figure S1F). The gene discussed is LINC00330; the disease is esophageal squamous cell carcinoma.