LINC00330 and esophageal squamous cell carcinoma: Additionally, when culturing ESCC cells with LINC00330 knocked down, we unexpectedly observed that these cells acquired mesenchymal-like morphological characteristics (morphology changed from polygonal or pebble-like to elongated spindle or spindle-shaped), whereas ESCC cells overexpressing LINC00330 maintained the morphological characteristics of epithelial cells better (the cell morphology was mostly polygonal or pebble-like) (Additional file 3: Figure S1J&K).