Furthermore, compared with those in the control group, the expression of the M1 markers CD80 and CD86 was significantly increased in the tumor tissues of the LINC00330 group (Additional file 3: Figure S2F, G), while M2 TAM infiltration was reduced (as indicated by the significant reduction in the expression of the M2 surface markers CD163 and CD206) (Additional file 3: Figure S2H, I). The gene discussed is CD163; the disease is neoplasm.