The results indicated that overexpression of CCL2 significantly exacerbated the promoting effects of LINC00330 knockdown on ESCC cell proliferation (Fig. 8F, and Additional file 3: Figure S7F), invasion (Fig. 8I, and Additional file 3: Figure S7I), and EMT (Fig. 8J, and Additional file 3: Figure S7J). The gene discussed is CCL2; the disease is esophageal squamous cell carcinoma.