Although the variation was extensive in Groups A and B, the median expression levels of MDM2 were significantly higher in Group A than in lipomas (fold change (fc): 3.22; P = 0.0007), and significantly higher in Group B than in Group A (fc: 2.9; P = 0.002); the increase in CDK4 expression was not significant (P > 0.05). The gene discussed is CDK4; the disease is lipoma.