We have verified that AD-BXD animals exhibit strong amyloid and neuroinflammatory responses with age and AD, display a high level of concordance with both familial and sporadic forms of human AD at the molecular and behavioral level9, and that female AD-BXD mice exhibit high translational alignment and conserved cell-type-specific signatures of resilience to AD with human AD cohorts11, but technical limitations have impeded our ability to explore the presence of tau epitopes across the AD-BXD panel. This evidence concerns the gene MAPT and Alzheimer disease.