The feasibility of human interventions (AA, L-Arg, Ang1) that in our murine model have proven effective both as a prophylactic and a therapeutic intervention, thus offering avenues that clinical trials targeting this signaling axis could now explore for the development of effective pathogen-agnostic, host-centered preventions or therapeutics for neonatal sepsis. This evidence concerns the gene ANGPT1 and Neonatal sepsis.