The plasma ANG1/ANG2 ratio was significantly negatively correlated with sPLA-2, while plasma Ang-1 and Ang-2 trended towards negative and positive correlations respectively for the Australian cohort of 22 sepsis cases and 40 controls (Fig. S2), further supporting an association between AA metabolism and the ANG1/ANG2 axis of vascular integrity (Fig. 4F). This evidence concerns the gene ANGPT1 and Sepsis.