CREM and neoplasm: We confirmed that most NETosis genes with the ability to distinct tumor and normal groups were jointly regulated by several TFs including REL, NFKB1, FOS, BCL3, CREM, CEBPB, HIVEP2 and ETS2. It is worth mentioning that representative genes were located very central to the NETosis related gene regulatory network, which provided confidence to take these genes to downstream analysis.