At the same time, a recent study also observed the expression of CXCL2 can induce the migration of neutrophils from the peripheral circuit to TME and might account for the liver metastasis after gemcitabine treatment, which might form feedforward recruitment of anti-tumor neutrophils and melatonin was validated to induced the expression of tumor cells rather than macrophages to recruit the neutrophils by upregulated CXCL242,46. The gene discussed is CXCL2; the disease is neoplasm.