Five TRIM expression was significantly upregulated (TRIM14, TRIM15, TRIM24, TRIM29, and TRIM31), and the other five TRIM genes showed decreased expression (TRIM1, TRIM3, TRIM9, TRIM22, and TRIM73) in both colon cancer (COAD) and rectal cancer (READ) (Fig. 1A, B). The gene discussed is TRIM22; the disease is colon adenocarcinoma.