TRIM22 and colonic neoplasm: Five TRIM expression was significantly upregulated (TRIM14, TRIM15, TRIM24, TRIM29, and TRIM31), and the other five TRIM genes showed decreased expression (TRIM1, TRIM3, TRIM9, TRIM22, and TRIM73) in both colon cancer (COAD) and rectal cancer (READ) (Fig. 1A, B).