Five TRIM expression was significantly upregulated (TRIM14, TRIM15, TRIM24, TRIM29, and TRIM31), and the other five TRIM genes showed decreased expression (TRIM1, TRIM3, TRIM9, TRIM22, and TRIM73) in both colon cancer (COAD) and rectal cancer (READ) (Fig. 1A, B). This evidence concerns the gene TRIM22 and malignant colon neoplasm.