Five TRIM expression was significantly upregulated (TRIM14, TRIM15, TRIM24, TRIM29, and TRIM31), and the other five TRIM genes showed decreased expression (TRIM1, TRIM3, TRIM9, TRIM22, and TRIM73) in both colon cancer (COAD) and rectal cancer (READ) (Fig. 1A, B). Here, TRIM15 is linked to malignant colon neoplasm.