We also examined the cytotoxic potential of circulating γδ T cell subsets and found significantly higher proportions of granzyme B+ Vδ1+ (54 ± 7.3%) and Vδ2+ (63 ± 6%) γδ T cells in CVID patients compared to healthy individuals (30 ± 3.9% and 35 ± 3.8%, respectively) (Fig. 1e). This evidence concerns the gene GZMB and common variable immunodeficiency.