The CMV/CVID patients also had significantly higher proportion of effector CD27−CX3CR1+ Vδ1+ and CD27−CD28− Vδ2+ γδ T cells (Supplementary Fig. 7c) and cytotoxic (granzyme B+) Vδ1+ and Vδ2+ cells (Supplementary Fig. 7d) compared to CMV− and CMV+ healthy individuals. Here, GZMB is linked to common variable immunodeficiency.