WB analysis herein indicated that phosphorylated-AMPK (p-AMPK) increased and phosphorylated-mTOR (p-mTOR) decreased, with concomitantly reduced autophagy in the pancreases of Reg4−/− mice during pancreatitis, but these alterations were circumvented by rReg4 administration (Fig. 5C, D). Here, MTOR is linked to pancreatitis.