To examine this, we treated the Reg4−/− mice with the CXCR4 antagonist plerixafor (AMD3100) with two daily injections (2.5 mg/kg body weight) initiated 1 day before the induction of pancreatitis and which lasted until day 7 when the mice were sacrificed (Fig. 7A). The gene discussed is CXCR4; the disease is pancreatitis.