To examine whether therapeutic administration of Reg4 reverses pancreatitis, recombinant Reg4 (rReg4) was injected twice (at 0 h and 8 h) into Reg4−/− mice with or without caerulein-introduction, and the mice were sacrificed 24 h after treatment (Fig. S8A). This evidence concerns the gene REG4 and pancreatitis.