Similar to the conclusions drawn from previous reports [33], in-depth analyses of TCGA data revealed at least 22 other tumor types that displayed higher C1orf112 expression in the lesion tissue than the corresponding normal tissues (Fig. 5D), and such differential expression profile also existed in osteosarcoma samples collected in the Gene Expression Omnibus database (GSE16088 and GSE33383) (Fig. 5E). The gene discussed is FIRRM; the disease is osteosarcoma.