Importantly, the multivariate analysis unveiled that YY1 expression served as an independent prognostic marker for both OS (HR 2.419, 95% CI 1.102 to 5.311, P = 0.028) and PFS (HR 2.256, 95% CI 1.152 to 4.419, P = 0.018) in CRC patients (Table 3). This evidence concerns the gene YY1 and colorectal carcinoma.