Next, preexisting CVD showed weak univariate positive associations with risk factors of the outcomes: DM (β = 0.265, P < 0.001), CRP (β = 0.162, P < 0.05), hs-cTnI (β = 0.230, P < 0.001) and NT-proBNP (β = 0.160, P < 0.05). This evidence concerns the gene NPPB and diabetes mellitus.