EWSR1 and Ewing sarcoma: Notably, the identification of the fusion gene EWS/FLI (FLI, a member of the ETS family of transcription factors) caused by the characteristic chromosomal translocation t(11;22)(q24;q12) is the molecular diagnostic feature of ESFT, occurs in 85% of individuals with ES (Balamuth and Womer 2010).