PDGF-D increased subacute bioavailability did not alter the projections of reactive GFAP+ astrocytes, indicating a preservation of the anisomorphic phenotype 2 weeks after ischemic stroke (VEH:36.41 ± 1.078; P125:37.833 ± 1.115; P250:37.638 ± 1.661). The gene discussed is PDGFD; the disease is ischemic stroke.