Our analysis showed that collagen IV reactivity at the basal membrane of the vasculature (Fig. 7e) remained unchanged 2 weeks after stroke (VEH:31.46 ± 10.55, P125:26.66 ± 3.919, P250:27.28 ± 7.546) (Fig. 7g) upon increasing PDGF-D subacute bioavailability. Here, PDGFD is linked to Stroke.