PDGF-D stimulation enriches the secretome of pericytes exposed to ischemia and reperfusion-like conditions by molecules involved in mediating vascular remodeling, namely IGFBP1, uPA, and VEGF, while reducing the expression of molecules involved in inhibiting angiogenesis, namely TSP1, IGFBP2, and serpin E1. The gene discussed is SERPINE1; the disease is ischemia.