The reduced microvascular density was associated with a diminution of the average diameter of CD31+ microvessels in the intralesional (P = 0.0331) (Fig. 2l) and the perilesional (P = 0.0025) (Fig. 2m) sites, outlining a deregulation of vascular structure translated by exacerbation of post-stroke stalling, constriction, and reduced patency. This evidence concerns the gene PECAM1 and stroke disorder.