PDGFD and Brain atrophy: Attenuation of PDGF-D post-stroke induction did not affect brain atrophy (VEH:8.120 ± 6.558, siRNA:13.94 ± 7.237) (Fig. 2d), whereas it aggravated IgG infiltration into the injured brain 1 week after stroke (P = 0.0489) (Fig. 2e), outlining an increased vascular permeability.