We next assessed neuronal degeneration using FJB staining (Fig. 3e), and found that PDGF-D dose-dependently reduced the density of FJB+ cells in the cortex (VEH vs. P125, P = 0.0652; VEH vs. P250; P = 0.0153) (Fig. 3f), as well as in the striatum (VEH vs. P125, P = 0.0087; VEH vs. P250, P = 0.0551) (Fig. 3g), 1 week after stroke. The gene discussed is PDGFD; the disease is Stroke.