Our analysis showed that PDGF-D did not affect brain atrophy (VEH:5.717 ± 6.829, P125:3.317 ± 6.496, P250:2.633 ± 7.787) (Fig. 3c), but strongly reduced IgG extravasation (VEH:35.2 ± 6.928, P125:26.91 ± 8.013; VEH vs. P250, P = 0.0013) (Fig. 3d) 1 week after ischemic stroke. This evidence concerns the gene PDGFD and ischemic stroke.