Furthermore, PDGF-D enhanced bioavailablity increased the average diameter of CD31+ microvessels in the intralesional (VEH:4.73 ± 0.7272, P125:5.178 ± 0.4283, P250:5.351 ± 0.5973) (Fig. 3k) as well as the perilesional (VEH:4.806 ± 0.7981, P125:5.588 ± 0.4129, P250:5.657 ± 0.61) (Fig. 3l) sites, 1 week after ischemic stroke. This evidence concerns the gene PECAM1 and ischemic stroke.