PECAM1 and Stroke: Afterwards, we evaluated tissue vascularization in the ipsilateral hemisphere using CD31 immunolabeling (Fig. 3h), and our analysis showed that PDGF-D dose-dependently increased the density of CD31+ microvessels in the intralesional (VEH:551.8 ± 63.32, P125:754.2 ± 166.9, P = 0.1082; VEH vs. P250, P = 0.0251) (Fig. 3i) as well as the perilesional (VEH vs. P125, P = 0.0104; VEH vs. P250, P = 0.0005) (Fig. 3j) sites, 1 week after stroke.