Our gene‐metabolite‐disease network analysis revealed that eight genes (SLC16A10, SLC7A8, SLC6A19, IL4l1, SLC6A14, IARS, SLC38A2, and SLC6A15) are linked to metabolites of which the CSF levels were significantly altered in our rat model of AD. The gene discussed is SLC6A15; the disease is Alzheimer disease.