Accordingly, in response to the COVID-19 pandemic, we constructed dozens of vaccine candidates incorporating SARS-CoV-2 structural components including the ~6.5-kb full-length spike S gene, the 2.7-kb receptor binding domain (RBD) gene, and a 1.3-kb nucleocapsid gene, along with Hoc- and Soc-fused SARS-CoV-2 genes controlled by the Hoc and/or Soc native promoters in a matter of weeks (23, 24, 72). Here, CHMP5 is linked to COVID-19.