Sleeping in the same room as a TB patient (a proxy for increased exposure to M.tb) was found to show a strong association with TB2-TB1>0.6IU/ml (OR 4.34, 95% CI 1.37–13.81), p = 0.013 as compared to sleeping in a different house to an index case (OR 0.51 (0.06–4.52) p = 0.545). This evidence concerns the gene REEP5 and tuberculosis.