Biomarkers producing immune response (e.g. transforming growth factor-β1 (TGF-β1), N-terminal portion of the B-type natriuretic propeptide, and vascular endothelial growth factor (VEGF)) play a crucial role as a mediator for immune response, result in periodontitis, especially people with chronic diseases, like diabetes [5, 6]. The gene discussed is VEGFA; the disease is diabetes mellitus.