To evaluate the role of DSP mutations in genetically mediated cardiomyopathy and myocarditis, we generated 2 patient-derived hiPSC lines for study, DSP c.4789G > T (p.E1597X) and DSP c.5851C > T (p.R1951X) (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI180254DS1; and Figure 1A). Here, DSP is linked to cardiomyopathy.