IFNG and neoplasm: Accumulating evidence suggests that hypoxia-induced TDSEVs can induce T cell apoptosis, suppress natural killer (NK) cell activity, inhibit type II macrophage expression dependent on IFN-γ, alter monocyte differentiation, and increase the population of myeloid-derived suppressor cells (MSDCs).72–74 Consequently, these immune response alterations lead to diminished immune surveillance and facilitate tumor evasion from immune recognition.