SLC2A1 and neoplasm: The overexpression of glucose transporter 1 (GLUT-1) facilitates increased glucose uptake by tumor cells, leading to metabolic reprogramming and significant alterations in the TME.159 The increased glucose uptake facilitated by overexpressed GLUT-1 has led to the development of sugar binders capable of traversing GLUT-1 and delivering anticancer agents without inhibiting GLUT-1, emerging as a promising strategy for targeted antitumor therapy.