CD8A and neoplasm: Compared to sub-thermoneutral temperature, mice living under thermoneutral housing temperature (30 °C) showed significant reductions in tumor growth rate and metastasis; tumor exhibited a more favorable TME with more antitumor CD8+T-cells and fewer pro-cancerous myeloid-derived suppressor cells (MDSCs) and regulatory T-cells (Tregs) [9–11].