CXCL12 and cholangiocarcinoma: The aim of this study was to investigate TLS function and its relationship with CXCL12 in cHCC–CCA and to clarify the distribution, constituents, and prognostic value of TLSs in the cHCC–CCA tissues of 137 patients, hoping to provide some insight into the accurate stratification, prognosis prediction, and treatment of patients with cHCC–CCA.