KEGG pathway analysis from downregulated DEmiRs after ITGB1 depletion showed enrichment in Glycosphingolipid biosynthesis-globo and isoglobo series, Amyotrophic lateral sclerosis (ALS) and Hippo signaling pathway-multiple species (Fig. 2E). Here, ITGB1 is linked to amyotrophic lateral sclerosis.