BID and cancer: The results manifested that BID overexpression was distinctly enriched in immune processes such as cytokine_cytokine_receptor_interaction, natural killer cell-mediated cytotoxicity, and antigen processing and presentation; while the down-regulation of BID was significantly enriched in insulin signaling pathway, WNT signaling pathway, renal cell carcinoma, pathways in cancer and MAPK signaling pathway (Fig. 7A).