We found that BID high expression was observably enriched in the immune process, while BID down-regulation was enriched in energy metabolism and cancer-related pathways, such as insulin signaling pathway, WNT signaling pathway, renal cell carcinoma, pathways in cancer, MAPK signaling pathway, etc. Metabolic changes are prevalent in several human cancer tissues. Here, BID is linked to hereditary clear cell renal cell carcinoma.