The results manifested that BID overexpression was distinctly enriched in immune processes such as cytokine_cytokine_receptor_interaction, natural killer cell-mediated cytotoxicity, and antigen processing and presentation; while the down-regulation of BID was significantly enriched in insulin signaling pathway, WNT signaling pathway, renal cell carcinoma, pathways in cancer and MAPK signaling pathway (Fig. 7A). Here, BID is linked to hereditary clear cell renal cell carcinoma.