A recent study has shown that the large introns do not seem to be important for PRKN expression 146, but may through the fragility of the region contribute to an increased risk of de novo germline variants in PRKN. Moreover, the fragility of the PRKN gene likely increases the risk of somatic PRKN mutations, which based on Parkin’s possible role as a tumor suppressor [136,137], could have implications for cancer susceptibility. Here, PRKN is linked to cancer.