MTOR and bacterial infectious disease: To examine the role of mTOR signaling in controlling bacterial infection, micewere treated with the mTOR inhibitor rapamycin (Rapa) and inoculatedsubcutaneously with Staphylococcus aureus in a model of SSTI.S. aureus achieved a significantly higher burden inRapa-treated mice than untreated mice (P < 0.0001), with~20-fold more colony-forming units (CFU) recovered from the lesion on day 7after infection in Rapa-treated mice (Fig.1A).