Crosstalk between mTOR and NF-κB signaling has beendescribed, especially in tumor cells (58),and several studies have observed an increase in IL-12 production from Rapa-treatedphagocytes upon activation (59, –, 61), though we did not observe a significant difference in IL-12production in the lesions of Rapa-treated animals. The gene discussed is TRERF1; the disease is neoplasm.