In liver stellate cell activation and hepatic fibrosis, despite an increase in lactate and acetyl‐CoA levels induced by the upregulation of glycolysis through HK2 expression, the impact was limited to histone lactylation and did not induce histone acetylation.[43] Therefore, these studies suggest functional differences in the patterns of histone lactylation and acetylation. This evidence concerns the gene HK2 and Hepatic fibrosis.