Subsequently, Non‐histone lactylation modifications have been reported, and they can also regulate the transcription of genes, such as those encoding HMGB,[66] PKM2,[64] HIF1α,[67] Snail1,[14] YY1,[68] and METTL3.[69] H3K18la is involved in the expression of homeostatic genes related to damage repair, such as Arg‐1, playing a crucial role in the mechanisms of homeostasis and healing in vivo.[23] In a single‐center, small‐sample clinical study on sepsis, researchers examined peripheral blood mononuclear cells from healthy volunteers and 35 critically ill patients (septic and nonseptic). This evidence concerns the gene PKM and Sepsis.