RETN and obesity due to melanocortin 4 receptor deficiency: While resistin has been shown to be increased in serum of women with PCOS,[20] its role in obesity and type 2 diabetes remains controversial[41, 42] and there are reports of decreased expression of resistin in adipose tissue of transgenic models of obesity.[43] The effect of androgens on adipokines and its implication in metabolic comorbidities of PCOS therefore warrants further investigation.