RETN and Insulin resistance: Finally, serum levels of IL‐18 has been shown to be higher in women with PCOS and suggested to be associated with insulin resistance and cardiovascular risk factors.[13, 14, 19] Similarly, the adipokine resistin (RETN) has been reported to be higher in circulation of women with PCOS.[20] IL‐18 and resistin levels were therefore assessed in plasma by ELISA.