Contrary, macrophages with an anti‐inflammatory phenotype are essential for maintaining insulin sensitivity in mice with diet‐induced obesity.[7] Eosinophils have been shown to sustain the anti‐inflammatory phenotype of macrophages through the release of IL‐4 and IL‐13.[8] Here we observed a lower frequency of eosinophils as well as reduced levels of IL‐4 and IL‐13 in VAT of DHT‐exposed mice, which could potentially influence the function of macrophages in adipose tissue. This evidence concerns the gene IL4 and obesity due to melanocortin 4 receptor deficiency.