Similarly, immune cells in visceral adipose tissue are known to play a pivotal role in regulating metabolic function and adipose tissue inflammation is widely believed to be the underlying cause of insulin resistance and type 2 diabetes in obesity.[5] Substantial evidence shows that macrophages with a proinflammatory phenotype can cause insulin resistance.[6] Adipose tissue macrophages are regulated in a complex network where adipokines and proinflammatory cytokines, such as IFN‐γ, trigger a more proinflammatory phenotype. This evidence concerns the gene IFNG and Insulin resistance.