Vice versa, despite a relatively high AF, only two mutations were exclusively detected in tumor biopsies (VPS13B (vacuolar protein sorting 13 homolog B), AF 0.09, Pat ID 1385 and APC, AF 0.2, Pat ID 1364), compared to 15 and 6 mutations that were detected only in plasma or stool, respectively. This evidence concerns the gene VPS13B and neoplasm.