TPCN2 and mucolipidosis type IV: Mechanistically, TPC2-dependent neuroprotection is linked to lysosomal exocytosis and autophagy activation, as assessed in mucolipidosis type IV (MLIV), Niemann-Pick type C1, Batten disease patient fibroblasts, and in iPSC- derived neurons from MLIV and Batten patients [68].