Macrophage polarization plays a crucial role in the inflammatory response following MI.34,35 Excessive M1 polarization and impaired M2 polarization have been associated with adverse cardiac remodeling.36,37 Exosome treatment demonstrated a proclivity toward promoting M2 macrophage polarization while suppressing M1 polarization, as evidenced by altered expression levels of markers such as iNOS and CD206. The gene discussed is MRC1; the disease is myocardial infarction.