ARC and Anxiety: This intervention effectively normalized deficits in ARC expression and consequently led to a reduction in adult anxiety and excessive alcohol consumption in a rat model that examined alcohol exposure during adolescence.104 Interestingly, dCas9-Kruppel-associated box (KRAB), in contrast, was found to promote repressive histone methylation at the ARC SARE, resulting in decreased ARC expression, the manifestation of anxiety-like behaviors, and increased alcohol consumption in the control group.