REN and atherosclerosis: These key active ingredients were suggested to mitigate inflammation and oxidative stress, curtail the proliferation of renal vascular smooth muscle cells, decrease the glomerular capillary systolic pressure, and improve the renal dysfunction and vascular injury by acting on the 29 key targets including TNF, IL6, ALB, EGFR, ACE, and MMP2, involving the fluid shear stress and atherosclerosis, HIF-1 signaling pathway, renin-angiotensin system, and AGE-RAGE signaling pathway in diabetic complications.