The results showed that GO:0051020 (GTpase binding), GO:0019901 (protein kinase binding), GO:0008047 (enzyme activator activity), GO:0010506 (regulation of autophagy), GO:0006914 (autophagy), GO:0031669 (cellular response to nutrient levels) and GO:0032006 (regulation of TOR signaling) were significantly regulated by the alterations of TBC1Ds in HCC (Figs. 6B and 6C). Here, WEE1 is linked to hepatocellular carcinoma.