NRGN and Encephalopathy: Moderate to severe cerebral injury:Plasma NRGN level:40 pg/ml (7–403 pg/ml); CSF NRGN level: 7 pg/ml (7–7 pg/ml)Cognitive abnormal or death: Plasma NRGN level 49.9 pg/ml (16.5–243.2 pg/ml)Abnormal motor: Plasma NRGN level 59.4 pg/ml (16.5–314.2 pg/ml)Abnormal language: Plasma NRGN level 38.0 pg/ml (165.5–2.8.2 pg/ml)* In CSF, NRGN level was inversely associated with cognitive, motor and language outcomes.* In plasma, NRGN level was directly associated with encephalopathy grade