Overall, while ROI numbers were limited for this analysis (n = 29 from CS cases, n = 10 from controls), the results suggest an immunologically active environment in CS vascular beds relative to controls, with increased expression of CD3, CD4, CD68, VISTA, CD45, HLA-DR, and CD11c (Supplemental Table S.9). Here, ITGAX is linked to Cowden syndrome 1.