To determine if the protective effect of TYK2 inhibition on T1D development in RIP-LCMV-GP mice was associated with altered innate or adaptive immune responses, flow cytometry analysis was performed on the whole blood, spleen, and pancreatic lymph nodes (PLN) of vehicle- and TYK2i-treated mice at days 3, 7, and 14 post-LCMV inoculation. This evidence concerns the gene TYK2 and type 1 diabetes mellitus.