We also evaluated AP-diABZI in a MMTV-PyMT model of spontaneous breast cancer, finding that systemic administration of AP-diABZI significantly reduced tumor burden without evidence of increased lung metastasis (Extended Data Fig. 4), which has been implicated as a potentially deleterious consequence of STING signaling in some preclinical models.59, 60. This evidence concerns the gene STING1 and neoplasm.