Likewise, both nAlb-diABZI and AP-diABZI mediated considerable shifts in the gene expression profile, with transcript signatures associated with increased immune cell infiltrate (immune cell trafficking, CD8+ T cells, NK cells, Th1 cells), tumor immunogenicity (antigen presentation, T cell priming, T cell recognition, costimulation, cytokine/interferon signaling), and cancer cell death/apoptosis, with AP-diABZI tending to exert a stronger effect relative to nAlb-diABZI (Fig. 5k–m, Fig. S26). This evidence concerns the gene CD8A and cancer.