STING activation can prime the immune system to stimulate a systemic, antigen-specific, antitumor T cell responses with potential to lead to generation of T cell memory.19, 61 Given evidence of increased antigen presentation, cancer cell killing, and T cell priming (Fig. 5), as well as protection from tumor re-challenge in mice with EMT6 tumors treated with AP-diABZI, we next assessed the capacity of AP-diABZI to stimulate a de novo tumor antigen-specific CD8+ T cell response. Here, STING1 is linked to cancer.