CD33 and acute myeloid leukemia: As sorbitol dehydrogenase (encoded by SORD) synthesizes fructose at the end of the polyol pathway, we profiled SORD abundance in human bone marrow using single cell transcriptomic data generated from the anti-CD123-CAR-T cell clinical trial (NCT04106076) performed at the University of Pennsylvania.35 Uniform manifold approximation and projection (UMAP) visualization revealed SORD expression in AML blasts (CD33+ and CD34+; Fig. 7A).