SLC2A5 and acute myeloid leukemia: Competition for nutrients can induce cellular energy deficits that ultimately impede CAR-T cell cytolytic function.12,22 We note however, that fructose is abundant in the bone marrow and periphery in AML.3 To determine the functional significance of our findings, we investigated if fructose supports CAR123-GLUT5 cytotoxicity using xCELLigence RTCA eSight technology.